FTIR-based spectroscopic analysis in the identification of clinically aggressive prostate cancer.

ABSTRACT: Fourier transform infrared (FTIR) spectroscopy is a vibrational spectroscopic technique that uses infrared radiation to vibrate molecular bonds within the sample that absorbs it. As different samples contain different molecular bonds or different configurations of molecular bonds, FTIR allows us to obtain chemical information on molecules within the sample. Fourier transform infrared microspectroscopy in conjunction with a principal component-discriminant function analysis (PC-DFA) algorithm was applied to the grading of prostate cancer (CaP) tissue specimens. The PC-DFA algorithm is used alongside the established diagnostic measures of Gleason grading and the tumour/node/metastasis system. Principal component-discriminant function analysis improved the sensitivity and specificity of a thr

SUBMITTER: Baker MJ 

PROVIDER: S-EPMC2600682 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature