Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types.

ABSTRACT: Tumour proliferation is one of the main biological phenotypes limiting cure in oncology. Extensive research is being performed to unravel the key players in this process. To exploit the potential of published gene expression data, creation of a signature for proliferation can provide valuable information on tumour status, prognosis and prediction. This will help individualizing treatment and should result in better tumour control, and more rapid and cost-effective research and development. From in vitro published microarray studies, two proliferation signatures were compiled. The prognostic value of these signatures was tested in five large clinical microarray data sets. More than 1000 patients with breast, renal or lung cancer were included. One of the signatures (110 genes) had significa

SUBMITTER: Starmans MH 

PROVIDER: S-EPMC2600688 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature