Epstein-Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis.
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ABSTRACT:
SUBMITTER: Isobe Y
PROVIDER: S-EPMC2600699 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Epstein-Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis.
Isobe Y Y Sugimoto K K Matsuura I I Takada K K Oshimi K K
British journal of cancer 20081104 11
We established two Epstein-Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-kappaB activation and the resultant sustenance of antiapoptotic proteins including Bcl-X(L) and FLIP(L/S). ...[more]
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