An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10.

ABSTRACT:

Background

A major challenge lies in understanding the complexities of gene regulation. Mutation of the transcription factor SOX10 is associated with several human diseases. The disease phenotypes reflect the function of SOX10 in diverse tissues including the neural crest, central nervous system and otic vesicle. As expected, the SOX10 expression pattern is complex and highly dynamic, but little is known of the underlying mechanisms regulating its spatiotemporal pattern. SOX10 expression is highly conserved between all vertebrates characterised.

Results

We have combined in vivo testing of DNA fragments in zebrafish and computational comparative genomics to identify the first regulatory regions of the zebrafish sox10 gene. Both approaches converged on the 3' end of the conser

SUBMITTER: Dutton JR 

PROVIDER: S-EPMC2601039 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature