Dynamic correlation between intrahost HIV-1 quasispecies evolution and disease progression.

ABSTRACT: Quantifying the dynamics of intrahost HIV-1 sequence evolution is one means of uncovering information about the interaction between HIV-1 and the host immune system. In the chronic phase of infection, common dynamics of sequence divergence and diversity have been reported. We developed an HIV-1 sequence evolution model that simulated the effects of mutation and fitness of sequence variants. The amount of evolution was described by the distance from the founder strain, and fitness was described by the number of offspring a parent sequence produces. Analysis of the model suggested that the previously observed saturation of divergence and decrease of diversity in later stages of infection can be explained by a decrease in the proportion of offspring that are mutants as the distance from the f

SUBMITTER: Lee HY 

PROVIDER: S-EPMC2602878 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature