Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.

ABSTRACT:

Background

Atopic eczema (AE) is a common chronic inflammatory skin disorder. In order to dissect the genetic background several linkage and genetic association studies have been performed. Yet very little is known about specific genes involved in this complex skin disease, and the underlying molecular mechanisms are not fully understood.

Methodology/findings

We used human DNA microarrays to identify a molecular picture of the programmed responses of the human genome to AE. The transcriptional program was analyzed in skin biopsy samples from lesional and patch-tested skin from AE patients sensitized to Malassezia sympodialis (M. sympodialis), and corresponding biopsies from healthy individuals. The most notable feature of the global gene-expression pattern observed in AE ski

SUBMITTER: Saaf AM 

PROVIDER: S-EPMC2603322 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature