Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.

ABSTRACT:

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The molecular networks underlying the lung response to hypoxia are not fully understood. We employed systems biology approaches to study temporal effects of intermittent or sustained hypoxia on gene expression in rat lungs. We obtained gene expression profiles from rats exposed to intermittent or sustained hypoxia lasting 0-30 days and identified differentially expressed genes, their patterns, biological processes, and regulatory networks critical for lung response to intermittent or sustained hypoxia. We validated selected genes with quantitative real-time PCR. Intermittent and sustained hypoxia induced two distinct sets of genes in rat lungs that displayed different temporal expression patterns. Intermittent hypoxia induced genes mostly involved in ion transport and ho

SUBMITTER: Wu W 

PROVIDER: S-EPMC2604785 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature