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Construction of a versatile high precision ambient ionization source for direct analysis and imaging.

ABSTRACT: The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) are described in full detail, including a complete parts list. The computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis of peptides and proteins ranging from 1 to 17 kDa. The high stability ionization source platform described herein demonstrates both the advantages of the new MALDESI source and versatility for application to numerous desorption and ionization techniques.

SUBMITTER: Sampson JS

PROVIDER: S-EPMC2605079 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Construction of a versatile high precision ambient ionization source for direct analysis and imaging.

Sampson Jason S JS Hawkridge Adam M AM Muddiman David C DC

Journal of the American Society for Mass Spectrometry 20080628 10

The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) are described in full detail, including a complete parts list. The computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis of peptides and proteins ranging from 1 to 17 kDa. The high stability ionization source platform described herein demonstrates both the advantages ...[more]

PMID: 18657438

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