Exploratory analysis of the copy number alterations in glioblastoma multiforme.

ABSTRACT:

Background

The Cancer Genome Atlas project (TCGA) has initiated the analysis of multiple samples of a variety of tumor types, starting with glioblastoma multiforme. The analytical methods encompass genomic and transcriptomic information, as well as demographic and clinical data about the sample donors. The data create the opportunity for a systematic screening of the components of the molecular machinery for features that may be associated with tumor formation. The wealth of existing mechanistic information about cancer cell biology provides a natural reference for the exploratory exercise.

Methodology/principal findings

Glioblastoma multiforme DNA copy number data was generated by The Cancer Genome Atlas project for 167 patients using 227 aCGH experiments, and was analyzed

SUBMITTER: Freire P 

PROVIDER: S-EPMC2605252 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature