Sex dependent imprinting effects on complex traits in mice.

ABSTRACT:

Background

Genomic imprinting is an epigenetic source of variation in quantitative traits that results from monoallelic gene expression, where commonly either only the paternally- or the maternally-derived allele is expressed. Imprinting has been shown to affect a diversity of complex traits in a variety of species. For several such quantitative traits sex-dependent genetic effects have been discovered, but whether imprinting effects also show such sex-dependence has yet to be explored. Moreover, theoretical work on the evolution of sex-dependent genomic imprinting effects makes specific predictions about the phenotypic patterns of such effects, which, however, have not been assessed empirically to date.

Results

Using a genome-scan for loci affecting a set of complex growth

SUBMITTER: Hager R 

PROVIDER: S-EPMC2605465 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature