PlasmoDraft: a database of Plasmodium falciparum gene function predictions based on postgenomic data.

ABSTRACT:

Background

Of the 5,484 predicted proteins of Plasmodium falciparum, the main causative agent of malaria, about 60% do not have sufficient sequence similarity with proteins in other organisms to warrant provision of functional assignments. Non-homology methods are thus needed to obtain functional clues for these uncharacterized genes.

Results

We present PlasmoDraft http://atgc.lirmm.fr/PlasmoDraft/, a database of Gene Ontology (GO) annotation predictions for P. falciparum genes based on postgenomic data. Predictions of PlasmoDraft are achieved with a Guilt By Association method named Gonna. This involves (1) a predictor that proposes GO annotations for a gene based on the similarity of its profile (measured with transcriptome, proteome or interactome data) with genes already

SUBMITTER: Brehelin L 

PROVIDER: S-EPMC2605471 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature