Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid.

ABSTRACT: A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

SUBMITTER: Singh SK 

PROVIDER: S-EPMC2605618 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature