DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.

ABSTRACT:

Purpose

About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-associated gene expression changes have been identified in colorectal cancers, but little overlap exists between signatures hindering an assessment of overall consistency. Little is known about the causes and downstream effects of differential gene expression.

Experimental design

DNA microarray data on 89 MSI and 140 microsatellite-stable (MSS) colorectal cancers from this study and 58 MSI and 77 MSS cases from three published reports were randomly divided into test and training sets. MSI-associated gene expression changes were assessed for cross-study consistency using training samples and validated as MSI classifier using test samples. Differences in biological pathways were identified by

SUBMITTER: Jorissen RN 

PROVIDER: S-EPMC2605660 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature