Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

ABSTRACT: The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification. We have shown previously that inactivation of the hepatic cytochrome P450 system through conditional deletion of POR (P450 oxidoreductase) induces hepatic steatosis, liver growth and P450 expression. We have exploited a new conditional model of POR deletion to investigate the mechanism underlying these changes. We demonstrate that P450 induction, liver growth and hepatic triacylglycerol (triglyceride) homoeostasis are intimately linked and provide evidence that the observed phenotypes result from hepatic accumulation of unsaturated fatty acids, which mediate these phenotypes by activation of the nuclear receptor CAR (constitutive andro

SUBMITTER: Finn RD 

PROVIDER: S-EPMC2605957 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature