The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.

ABSTRACT:

Background

Histone acetyltransferases (HATs) play critical roles in the regulation of chromatin structure and gene expression. Arabidopsis genome contains 12 HAT genes, but the biological functions of many of them are still unknown. In this work, we studied the evolutionary relationship and cellular functions of the two Arabidopsis HAT genes homologous to the MYST family members.

Results

An extensive phylogenetic analysis of 105 MYST proteins revealed that they can be divided into 5 classes, each of which contains a specific combination of protein modules. The two Arabidopsis MYST proteins, HAM1 and HAM2, belong to a "green clade", clearly separated from other families of HATs. Using a reverse genetic approach, we show that HAM1 and HAM2 are a functionally redundant pair of

SUBMITTER: Latrasse D 

PROVIDER: S-EPMC2606689 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature