A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women.

ABSTRACT:

Objective

Subclinical inflammation is linked with the development of type 2 diabetes, and epidemiologic data suggest that this association may be stronger in women. Although small clinical studies have shown a prominent hypoglycemic effect of short-term high-dose aspirin, no randomized trials have directly evaluated the efficacy of aspirin in diabetes prevention at doses acceptable for use in routine clinical practice. We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women.

Research design and methods

Subjects were enrolled in the Women's Health Study, a 10-year randomized double-blind, placebo-controlled trial of aspirin and vitamin E for primary prevention of cardiovascular disease and cancer. Betw

SUBMITTER: Pradhan AD 

PROVIDER: S-EPMC2606820 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature