Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy.

ABSTRACT:

Objective

Mitochondrial superoxide levels are elevated in the retina in diabetes, and manganese superoxide dismutase overexpression prevents the development of retinopathy. Superoxide inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which activates major pathways implicated in diabetic complications, including advanced glycation end products (AGEs), protein kinase C, and hexosamine pathway. Our aim is to investigate the role of GAPDH in the development and progression of diabetic retinopathy and to elucidate the mechanism.

Research design and methods

Rats with streptozotocin-induced diabetes were in a state of poor control (GHb >11%) for 12 months, good control (GHb <7) soon after induction of diabetes, or poor control for 6 months with 6 months' good control. Reti

SUBMITTER: Kanwar M 

PROVIDER: S-EPMC2606877 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature