Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

ABSTRACT:

Objective

Two recent genome-wide association (GWA) studies have revealed novel loci for type 1 diabetes, a common multifactorial disease with a strong genetic component. To fully utilize the GWA data that we had obtained by genotyping 563 type 1 diabetes probands and 1,146 control subjects, as well as 483 case subject-parent trios, using the Illumina HumanHap550 BeadChip, we designed a full stage 2 study to capture other possible association signals.

Research design and methods

From our existing datasets, we selected 982 markers with P < 0.05 in both GWA cohorts. Genotyping these in an independent set of 636 nuclear families with 974 affected offspring revealed 75 markers that also had P < 0.05 in this third cohort. Among these, six single nucleotide polymorphisms in five no

SUBMITTER: Grant SF 

PROVIDER: S-EPMC2606889 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature