Ontology highlight
ABSTRACT:
SUBMITTER: Guenther MG
PROVIDER: S-EPMC2607073 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Genes & development 20081201 24
Mixed-lineage leukemia (MLL) fusion proteins are potent inducers of leukemia, but how these proteins generate aberrant gene expression programs is poorly understood. Here we show that the MLL-AF4 fusion protein occupies developmental regulatory genes important for hematopoietic stem cell identity and self-renewal in human leukemia cells. These MLL-AF4-bound regions have grossly altered chromatin structure, with histone modifications catalyzed by trithorax group proteins and DOT1 extending across ...[more]