A putative ABC transporter is involved in negative regulation of biofilm formation by Listeria monocytogenes.

ABSTRACT: Listeria monocytogenes may persist for long periods in food processing environments. In some instances, this may be due to aggregation or biofilm formation. To investigate the mechanism controlling biofilm formation in the food-borne pathogen L. monocytogenes, we characterized LM-49, a mutant with enhanced ability of biofilm formation generated via transposon Tn917 mutagenesis of L. monocytogenes 4b G. In this mutant, a Tn917 insertion has disrupted the coding region of the gene encoding a putative ATP-binding cassette (ABC) transporter permease identical to Lmof2365_1771 (a putative ABC transporter permease) presented in the sequenced strain L. monocytogenes strain 4b F2365. This disrupted gene, denoted lm.G_1771, encoded a protein with 10 transmembrane helices. The revertant, LM-49RE, wa

SUBMITTER: Zhu X 

PROVIDER: S-EPMC2607177 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature