ElliPro: a new structure-based tool for the prediction of antibody epitopes.

ABSTRACT:

Background

Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics. A correlation between antigenicity, solvent accessibility, and flexibility in proteins was demonstrated. Subsequently, Thornton and colleagues proposed a method for identifying continuous epitopes in the protein regions protruding from the protein's globular surface. The aim of this work was to implement that method as a web-tool and evaluate its performance on discontinuous epitopes known from the structures of antibody-protein complexes.

Results

Here we present ElliPro, a web-tool that implements Thornton's method and, together with a residue clustering algorithm, the MODELLER program and the Jmol viewer, allows the pred

SUBMITTER: Ponomarenko J 

PROVIDER: S-EPMC2607291 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature