Genomic expression of mesenchymal stem cells to altered nanoscale topographies.

ABSTRACT: The understanding of cellular response to the shape of their environment would be of benefit in the development of artificial extracellular environments for potential use in the production of biomimetic surfaces. Specifically, the understanding of how cues from the extracellular environment can be used to understand stem cell differentiation would be of special interest in regenerative medicine. In this paper, the genetic profile of mesenchymal stem cells cultured on two osteogenic nanoscale topographies (pitted surface versus raised islands) are compared with cells treated with dexamethasone, a corticosteroid routinely used to stimulate bone formation in culture from mesenchymal stem cells, using 19k gene microarrays as well as 101 gene arrays specific for osteoblast and endothelial biolo

SUBMITTER: Dalby MJ 

PROVIDER: S-EPMC2607434 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature