Prevalence of sheep infected with classical scrapie in Great Britain: integrating multiple sources of surveillance data for 2002.

ABSTRACT: Estimates for the prevalence of sheep infected with classical scrapie are essential for assessing the efficacy of control strategies that have been implemented in Great Britain (GB). Here a back-calculation approach was used to estimate the prevalence in the GB national flock by integrating data on reported cases and the results of abattoir and fallen stock surveys for 2002. Prevalence estimates ranged from 0.33 to 2.06%, depending on the estimates used for the frequencies of prion protein (PrP) genotypes in the national flock and the stage of incubation at which the diagnostic tests used are able to detect infected animals. The risk of infection was found to be higher than that of clinical disease, especially in those PrP genotypes that have a later age at onset of clinical disease. Moreo

SUBMITTER: Gubbins S 

PROVIDER: S-EPMC2607439 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature