Transporter molecules influence the gene expression in HeLa cells.

ABSTRACT: Progresses in biology and pharmacology led to highly specific bioactive substances, but their poor bioavailability at the site of action is a result of their physico-chemical properties. Various design approaches for transport carrier molecules facilitating the cellular entry of bioactive substances could help to reach their molecular target in cells and tissues. The transfer efficacy and the subsequent pharmacological effects of the cargo molecules are well investigated, but the investigations of effects of the carrier molecules themselves on the target cells or tissues remain necessary. A special attention should be paid to the differential gene expression, particularly in the interpretation of the data achieved by highly specific active pharmaceutical products. After application of tran

SUBMITTER: Waldeck W 

PROVIDER: S-EPMC2610340 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature