Using pathway signatures as means of identifying similarities among microarray experiments.

ABSTRACT: Widespread use of microarrays has generated large amounts of data, the interrogation of the public microarray repositories, identifying similarities between microarray experiments is now one of the major challenges. Approaches using defined group of genes, such as pathways and cellular networks (pathway analysis), have been proposed to improve the interpretation of microarray experiments. We propose a novel method to compare microarray experiments at the pathway level, this method consists of two steps: first, generate pathway signatures, a set of descriptors recapitulating the biologically meaningful pathways related to some clinical/biological variable of interest, second, use these signatures to interrogate microarray databases. We demonstrate that our approach provides more reliable re

SUBMITTER: Beltrame L 

PROVIDER: S-EPMC2610483 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature