The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples.

ABSTRACT:

Objective

To assess the association and combined effect on the risk of age-related macular degeneration (AMD) by the HtrA1 and complement factor H (CFH) polymorphisms, smoking, and serum cholesterol.

Design

Clinic-based and population-based case control study.

Participants

A total of 805 AMD cases and 921 controls from The Eye Clinic of National Eye Institute, Age-Related Eye Diseases Study, Blue Mountain Eye Study Cohort, and Minnesota Lions Eye Bank.

Methods

DNA samples were genotyped for polymorphisms of rs11200638 in HtrA1 promoter and rs380390 in CFH. HtrA1 protein in ocular tissue was measured. Interactions of the HtrA1 risk allele with the CFH risk variant, smoking status, and cholesterol were assessed.

Main outcome measures

AMD was evaluated by r

SUBMITTER: Tuo J 

PROVIDER: S-EPMC2610681 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature