The oxidative mannich reaction catalyzed by dirhodium caprolactamate.

ABSTRACT: Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C-H oxidation of a tertiary amine followed by nucleophilic capture. This green transformation is conducted in protic solvent using inexpensive T-HYDRO (70% t-BuOOH in water). Synthetically valuable gamma-aminoalkyl butenolides are obtained.

SUBMITTER: Catino AJ 

PROVIDER: S-EPMC2610808 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature