Study design and methods of the BoTULS trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A.

ABSTRACT:

Background

Following a stroke, 55-75% of patients experience upper limb problems in the longer term. Upper limb spasticity may cause pain, deformity and reduced function, affecting mood and independence. Botulinum toxin is used increasingly to treat focal spasticity, but its impact on upper limb function after stroke is unclear.The aim of this study is to evaluate the clinical and cost effectiveness of botulinum toxin type A plus an upper limb therapy programme in the treatment of post stroke upper limb spasticity.

Methods

Trial design

A multi-centre open label parallel group randomised controlled trial and economic evaluation.

Participants

Adults with upper limb spasticity at the shoulder, elbow, wrist or hand and reduced upper limb function due to stroke mor

SUBMITTER: Rodgers H 

PROVIDER: S-EPMC2611962 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature