Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli.

ABSTRACT:

Background

The zinc homeostasis system in Escherichia coli is one of the most intensively studied prokaryotic zinc homeostasis systems. Its underlying regulatory machine consists of repression on zinc influx through ZnuABC by Zur (Zn2+ uptake regulator) and activation on zinc efflux via ZntA by ZntR (a zinc-responsive regulator). Although these transcriptional regulations seem to be well characterized, and there is an abundance of detailed in vitro experimental data available, as yet there is no mathematical model to help interpret these data. To our knowledge, the work described here is the first attempt to use a mathematical model to simulate these regulatory relations and to help explain the in vitro experimental data.

Results

We develop a unified mathematical model consi

SUBMITTER: Cui J 

PROVIDER: S-EPMC2611976 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature