Differential replication dynamics for large and small Vibrio chromosomes affect gene dosage, expression and location.

ABSTRACT:

Background

Replication of bacterial chromosomes increases copy numbers of genes located near origins of replication relative to genes located near termini. Such differential gene dosage depends on replication rate, doubling time and chromosome size. Although little explored, differential gene dosage may influence both gene expression and location. For vibrios, a diverse family of fast growing gammaproteobacteria, gene dosage may be particularly important as they harbor two chromosomes of different size.

Results

Here we examined replication dynamics and gene dosage effects for the separate chromosomes of three Vibrio species. We also investigated locations for specific gene types within the genome. The results showed consistently larger gene dosage differences for the large c

SUBMITTER: Dryselius R 

PROVIDER: S-EPMC2612033 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature