Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells.

ABSTRACT: The intracellular gram-negative bacterial pathogen Salmonella enterica serovar Typhimurium gains entry into nonphagocytic cells by manipulating the assembly of the host actin cytoskeleton. S. enterica serovar Typhimurium entry requires a functional type III secretion system, a conduit through which bacterial effector proteins are directly translocated into the host cytosol. We and others have previously reported the enhancement of tyrosine kinase activities during Salmonella serovar Typhimurium infection; however, neither specific kinases nor their targets have been well characterized. In this study, we investigated the roles of the cellular Abelson tyrosine kinase (c-Abl) and the related protein Arg in the context of serovar Typhimurium infection. We found that bacterial internalization w

SUBMITTER: Ly KT 

PROVIDER: S-EPMC2612273 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature