Shifts in the selection-drift balance drive the evolution and epidemiology of foot-and-mouth disease virus.

ABSTRACT: Foot-and-mouth disease virus (FMDV) is the causative agent of an acute vesicular disease affecting wild and domesticated animals. Despite the economic burden of the disease and all efforts to eradicate it, FMD outbreaks continue to emerge unexpectedly in developed and developing countries. Correlation of the mutational dynamics of the virus with its epidemiology remains unexplored. Analysis of 103 complete genomes representing the seven serotypes shows the important role that selection plays in the genomic evolution of viral isolates for serotypes. We identified selection and relaxed constraints due to genetic drift through analyses of synonymous sites. Finally, we investigated interactions between mutations that showed coevolving patterns and analyzed, based on protein structures, slightl

SUBMITTER: Tully DC 

PROVIDER: S-EPMC2612391 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature