The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.

ABSTRACT: Bacterial infections of the lungs of cystic fibrosis (CF) patients cause major complications in the treatment of this common genetic disease. Burkholderia cenocepacia infection is particularly problematic since this organism has high levels of antibiotic resistance, making it difficult to eradicate; the resulting chronic infections are associated with severe declines in lung function and increased mortality rates. B. cenocepacia strain J2315 was isolated from a CF patient and is a member of the epidemic ET12 lineage that originated in Canada or the United Kingdom and spread to Europe. The 8.06-Mb genome of this highly transmissible pathogen comprises three circular chromosomes and a plasmid and encodes a broad array of functions typical of this metabolically versatile genus, as well as num

SUBMITTER: Holden MT 

PROVIDER: S-EPMC2612433 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature