DegU and Spo0A jointly control transcription of two loci required for complex colony development by Bacillus subtilis.

ABSTRACT: Biofilm formation is an example of a multicellular process which depends on cooperative behavior and differentiation within a bacterial population. Our findings indicate that there is a complex feedback loop that maintains the stoichiometry of the extracellular matrix and other proteins required for complex colony development by Bacillus subtilis. Analysis of the transcriptional regulation of two DegU-activated genes that are required for complex colony development by B. subtilis revealed additional involvement of global regulators that are central to controlling biofilm formation. Activation of transcription from both the yvcA and yuaB promoters requires DegU approximately phosphate, but transcription is inhibited by direct AbrB binding to the promoter regions. Inhibition of transcription

SUBMITTER: Verhamme DT 

PROVIDER: S-EPMC2612447 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature