Dynamical modeling of the cholesterol regulatory pathway with Boolean networks.

ABSTRACT:

Background

Qualitative dynamics of small gene regulatory networks have been studied in quite some details both with synchronous and asynchronous analysis. However, both methods have their drawbacks: synchronous analysis leads to spurious attractors and asynchronous analysis lacks computational efficiency, which is a problem to simulate large networks. We addressed this question through the analysis of a major biosynthesis pathway. Indeed the cholesterol synthesis pathway plays a pivotal role in dislypidemia and, ultimately, in cancer through intermediates such as mevalonate, farnesyl pyrophosphate and geranyl geranyl pyrophosphate, but no dynamic model of this pathway has been proposed until now.

Results

We set up a computational framework to dynamically analyze large biolog

SUBMITTER: Kervizic G 

PROVIDER: S-EPMC2612667 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature