Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.

ABSTRACT:

Background

Host adhesion molecules play a significant role in the pathogenesis of Plasmodium falciparum malaria and changes in their structure or levels in individuals can influence the outcome of infection. The aim of this study was to investigate the association of SNPs of three adhesion molecule genes, ICAM1, PECAM1 and CD36, with severity of falciparum malaria in a malaria-endemic and a non-endemic region of India.

Methods

The frequency distribution of seven selected SNPs of ICAM1, PECAM1 and CD36 was determined in 552 individuals drawn from 24 populations across India. SNP-disease association was analysed in a case-control study format. Genotyping of the population panel was performed by Sequenom mass spectroscopy and patient/control samples were genotyped by SNaPshot m

SUBMITTER: Sinha S 

PROVIDER: S-EPMC2612678 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature