Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients.

ABSTRACT:

Background

Studies on asbestos-induced tumourigenesis have indicated the role of, e.g., reactive oxygen/nitrogen species, mitochondria, as well as NF-kappaB and MAPK signalling pathways. The exact molecular mechanisms contributing to asbestos-mediated carcinogenesis are, however, still to be characterized.

Methods

In this study, gene expression data analyses together with gene annotation data from the Gene Ontology (GO) database were utilized to identify pathways that are differentially regulated in lung and tumour tissues between asbestos-exposed and non-exposed lung cancer patients. Differentially regulated pathways were identified from gene expression data from 14 asbestos-exposed and 14 non-exposed lung cancer patients using custom-made software and Iterative Group Analy

SUBMITTER: Ruosaari S 

PROVIDER: S-EPMC2612681 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature