Transcriptional response of the murine mammary gland to acute progesterone exposure.

ABSTRACT: Our mechanistic understanding of progesterone's involvement in murine mammary morphogenesis and tumorigenesis is dependent on defining effector pathways responsible for transducing the progesterone signal into a morphogenetic response. Toward this goal, microarray methods were applied to the murine mammary gland to identify novel downstream gene targets of progesterone. Consistent with a tissue undergoing epithelial expansion, mining of the progesterone-responsive transcriptome revealed the up-regulation of functional gene classes involved in epithelial proliferation and survival. Reassuringly, signaling pathways previously reported to be responsive to progesterone were also identified. Mining this informational resource for rapidly induced genes, we identified "inhibitor of differentiatio

SUBMITTER: Fernandez-Valdivia R 

PROVIDER: S-EPMC2613059 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature