The role of insulin receptor signaling in zebrafish embryogenesis.

ABSTRACT: Insulin receptor (IR) signaling is considered to be important in growth and development in addition to its major role in metabolic homeostasis. The metabolic role of insulin in carbohydrate and lipid metabolism is extensively studied. In contrast, the role of IR activation during embryogenesis is less understood. To address this, we examined the function of the IR during zebrafish development. Zebrafish express two isoforms of IR (insra and insrb). Both isoforms were cloned and show high homology to the human insulin receptor and can functionally substitute for the human IR in fibroblasts derived from insr gene-deleted mice. Gene expression studies reveal that these receptors are expressed at moderate levels in the central nervous system during development. Morpholino-mediated selective kn

SUBMITTER: Toyoshima Y 

PROVIDER: S-EPMC2613066 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature