Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism.

ABSTRACT:

Background

Eukaryotic gene expression is a complex process involving multiple cis and trans activating molecules to either facilitate or inhibit transcription. In recent years, many studies have focused on the role of acetylation of histone proteins in modulating transcription, whereas deacetylation of these same proteins is associated with inactivation or repression of gene expression. This study explores gene expression in HepG2 and F9 cell lines treated with Trichostatin A (TSA), a potent histone deacetylase inhibitor.

Results

These experiments show that TSA treatment results in clear repression of genes involved in the cholesterol biosynthetic pathway as well as other associated pathways including fatty acid biosynthesis and glycolysis. TSA down regulates 9 of 15 genes i

SUBMITTER: Chittur SV 

PROVIDER: S-EPMC2613157 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature