Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice.

ABSTRACT: Sympathetic nervous system development depends upon many factors that mediate neuron migration, differentiation and survival. Target tissue-derived nerve growth factor (NGF) signaling-induced gene expression is required for survival, differentiation and target tissue innervation of post-migratory sympathetic neurons. However, the transcriptional regulatory mechanisms mediated by NGF signaling are very poorly defined. Here, we identify Egr3, a member of the early growth response (Egr) family of transcriptional regulators, as having an important role in sympathetic nervous system development. Egr3 is regulated by NGF signaling and it is expressed in sympathetic neurons during development when they depend upon NGF for survival and target tissue innervation. Egr3-deficient mice have severe sym

SUBMITTER: Eldredge LC 

PROVIDER: S-EPMC2613541 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature