A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.

ABSTRACT:

Background

Despite evidence of a genetic role in stroke, the identification of common genetic risk factors for this devastating disorder remains problematic. We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same.

Methods

We applied a genome-wide high-density single-nucleotide-polymorphism (SNP) genotyping approach to a cohort of samples with and without ischaemic stroke (n=278 and 275, respectively), and did an association analysis adjusted for known confounders in a final cohort of 249 cases and 268 controls. More than 400,000 unique SNPs were assayed.

Findings

We produced more than 200 million genotypes in 55

SUBMITTER: Matarin M 

PROVIDER: S-EPMC2613843 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature