Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat.

ABSTRACT:

Background

The goal of these studies was to characterize the transcriptional network regulating changes in gene expression in the remnant liver of the rat after 70% partial hepatectomy (PHx) during the early phase response including the transition of hepatocytes from the quiescent (G0) state and the onset of the G1 phase of the cell cycle.

Results

The transcriptome of remnant livers was monitored at 1, 2, 4, and 6 hours after PHx using cDNA microarrays. Differentially regulated genes were grouped into six clusters according their temporal expression profiles. Promoter regions of genes in these clusters were examined for shared transcription factor binding sites (TFBS) by comparing enrichment of each TFBS relative to a reference set using the Promoter Analysis and Interaction

SUBMITTER: Juskeviciute E 

PROVIDER: S-EPMC2613928 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature