Testing the accuracy of eukaryotic phylogenetic profiles for prediction of biological function.

ABSTRACT: A phylogenetic profile captures the pattern of gene gain and loss throughout evolutionary time. Proteins that interact directly or indirectly within the cell to perform a biological function will often co-evolve, and this co-evolution should be well reflected within their phylogenetic profiles. Thus similar phylogenetic profiles are commonly used for grouping proteins into functional groups. However, it remains unclear how the size and content of the phylogenetic profile impacts the ability to predict function, particularly in Eukaryotes. Here we developed a straightforward approach to address this question by constructing a complete set of phylogenetic profiles for 31 fully sequenced Eukaryotes. Using Gene Ontology as our gold standard, we compared the accuracy of functional predictions m

SUBMITTER: Singh S 

PROVIDER: S-EPMC2614202 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature