Dissection of functional residues in receptor activity-modifying proteins through phylogenetic and statistical analyses.

ABSTRACT: Type I and type-II functional divergences have been stated to highlight specific residues carrying out differential functions in evolutionary-divergent protein clusters from a single common ancestor. Briefly, type I analysis is based on residue constraints reflecting a gain of function just in one cluster of an entire family of proteins; while the type-II approach is based on residue constraints showing a different chemical nature in every cluster of a protein family. This last evidence is understood as differential functionality among clusters. The Receptor Activity-Modifying Proteins constitute a family characterized by its paralogous distribution in vertebrates. They are known as G-Protein Coupled Receptor modulators. Although several studies have determined their involvement in ligand

SUBMITTER: Benitez-Paez A 

PROVIDER: S-EPMC2614204 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature