Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

ABSTRACT:

Background

Understanding the design logic of living systems requires the understanding and comparison of proteomes. Proteomes define the commonalities between organisms more precisely than genomic sequences. Because uncertainties remain regarding the accuracy of proteomic data, several issues need to be resolved before comparative proteomics can be fruitful.

Results

The Saccharomyces cerevisiae proteome presents the highest quality proteomic data available. To evaluate the accuracy of these data, we intensively mapped a proteomic environment, termed 'Chromatin Central', which encompasses eight protein complexes, including the major histone acetyltransferases and deacetylases, interconnected by twelve proteomic hyperlinks. Using sequential tagging and a new method to eliminat

SUBMITTER: Shevchenko A 

PROVIDER: S-EPMC2614481 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature