Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting.

ABSTRACT:

Background

Imprinted genes are exclusively expressed from one of the two parental alleles in a parent-of-origin-specific manner. In mammals, nearly 100 genes are documented to be imprinted. To understand the mechanism behind this gene regulation and to identify novel imprinted genes, common features of DNA sequences have been analyzed; however, the general features required for genomic imprinting have not yet been identified, possibly due to variability in underlying molecular mechanisms from locus to locus.

Results

We performed a thorough comparative genomic analysis of a single locus, Impact, which is imprinted only in Glires (rodents and lagomorphs). The fact that Glires and primates diverged from each other as recent as 70 million years ago makes comparisons between impr

SUBMITTER: Okamura K 

PROVIDER: S-EPMC2614492 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature