Proteomics studies confirm the presence of alternative protein isoforms on a large scale.

ABSTRACT:

Background

Alternative splicing of messenger RNA permits the formation of a wide range of mature RNA transcripts and has the potential to generate a diverse spectrum of functional proteins. Although there is extensive evidence for large scale alternative splicing at the transcript level, there have been no comparable studies demonstrating the existence of alternatively spliced protein isoforms.

Results

Recent advances in proteomics technology have allowed us to carry out a comprehensive identification of protein isoforms in Drosophila. The analysis of this proteomic data confirmed the presence of multiple alternative gene products for over a hundred Drosophila genes.

Conclusions

We demonstrate that proteomics techniques can detect the expression of stable alternative

SUBMITTER: Tress ML 

PROVIDER: S-EPMC2614494 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature