Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells.

ABSTRACT:

Background

Ets1 is an oncogene that functions as a transcription factor and regulates the activity of many genes potentially important for tumor initiation and progression. Interestingly, the Ets1 oncogene is over-expressed in many human squamous cell cancers and over-expression is highly correlated with invasion and metastasis. Thus, Ets1 is believed to mainly play a role in later stages of the oncogenic process, but not early events.

Methodology/principal findings

To better define the role of Ets1 in squamous cell carcinogenesis, we generated a transgenic mouse model in which expression of the Ets1 oncogene could be temporally and spatially regulated. Upon Ets1 induction in differentiating cells of stratified squamous epithelium, these mice exhibited dramatic changes in ep

SUBMITTER: Nagarajan P 

PROVIDER: S-EPMC2615206 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature