D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes.

ABSTRACT:

Objective

Certain D2 dopamine receptor Taq 1A genotypes (A1A1, A1A2) have been associated with obesity and substance abuse. We hypothesized that their presence would be associated with reduced efficacy of dietary interventions in individuals with type 2 diabetes.

Methods

In the course of a randomized clinical trial in an outpatient research center in which 93 adults with type 2 diabetes were assigned to a low-fat vegan diet or a diet following 2003 American Diabetes Association guidelines for 74 wk, Taq 1A genotype was determined. Nutrient intake, body weight, and hemoglobin A1c (A1c) were measured over 74 wk.

Results

The A1 allele was highly prevalent, occurring in 47% of white participants (n = 49), which was significantly higher than the 29% prevalence previously r

SUBMITTER: Barnard ND 

PROVIDER: S-EPMC2615385 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature